In genetics, loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal region are lost. [1] .

4 days ago · LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically containing a gene or group of genes).

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in …

What does LOH stand for? LOH abbreviation. Define LOH at AcronymFinder.com.

Loss of heterozygosity (LOH) is defined as the loss of a normal allele at a specific locus in a cell’s genome that already contains a deleterious mutation on the corresponding allele.

When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor suppressor gene. Also called LOH.

Jun 10, 2025 · In this article, we will provide an in-depth examination of the role of LOH in cell biology, focusing on its effects on cellular processes and disease mechanisms. LOH can significantly alter …