EurekAlert!

New insights: a natural small molecule isowalsuranolide targeting TrxR1/2 and triggering self-eating (autophagy) to combat cancer

Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...
ascopubs.org

p53 pathway genes' mutations as prognostic factors in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC): A single center study.

Investigation of the association of CTRB2 exon 6 deletion with time to progression and overall survival in pancreatic ductal adenocarcinoma. This is an ASCO Meeting Abstract from the 2025 ASCO ...
ascopubs.org

TLR9 agonists as a potential therapeutic option for B-ALL patients with low P53 expression.

A phase I study of allogeneic anti-CD19 CAR-T therapy for patients with CD19+ relapsed/refractory acute B-lymphoblastic leukemia. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I.
Medical Xpress

Scientists aim to repair or replace p53 to combat cancer

Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with regulatory processes to prevent this chaos. One such mechanism involves a ...